Frog vocal sacs-inspired soft acoustic system with continuously tunable resonance for sound emission and stethoscopic sensing
To overcome limitations of flexible thermoacoustic devices in low-frequency emission and sensing, we present a resonance-adjustable graphene sound device (RAGSD) inspired by frog vocal sacs. Integrating laser-induced graphene (LIG) with a deformable cavity, RAGSD provides continuous tuning from 922.12 to 1762.90 hertz. A dynamic, continuously tunable electro-mechano-acoustical model explains the mechanism and predicts frequency with [Formula: see text] . In emission, a 25.34-decibel sound pressure level gain was observed at resonance, enabling controllable, frequency-selective voice amplification for personalized output. In sensing, the LIG piezoresistive readout delivers sensitive transduction, while resonance matching amplifies weak, high-frequency cardiac sounds. Wearable tests on healthy volunteers and patients recorded clear S1/S2 and pathological murmurs. Integrated with AuscNet-H, a deep learning algorithm designed for heart sound classification, the system achieved 99.375% accuracy across four clinical classes. Under inflation, no false negatives occurred, and misclassifications among similar diseases were fewer than with a commercial electronic stethoscope. These results demonstrate a practical path toward intelligent, wearable auscultation.
Authors
- Chuting Liu (ORCID: https://orcid.org/0009-0001-6810-3634)
- Lvjie Chen (ORCID: https://orcid.org/0009-0008-0931-0116)
- Tian‐Ling Ren (ORCID: https://orcid.org/0000-0002-7330-0544)
- Jingzhi Wu (ORCID: https://orcid.org/0000-0003-3781-0528)
- Binbin Yan (ORCID: https://orcid.org/0009-0000-6775-9132)
- Jianping Jiang (ORCID: https://orcid.org/0009-0000-4244-2112)
- Bo Li (ORCID: https://orcid.org/0000-0001-8782-2485)
- Yancong Qiao (ORCID: https://orcid.org/0000-0003-0979-6853)
- Chang Liu (ORCID: https://orcid.org/0009-0000-5228-5018)
- Ranbo Yu (ORCID: https://orcid.org/0000-0003-3028-190X)
- Xiaoli Qu (ORCID: https://orcid.org/0000-0003-4230-0434)
- Qinghong Zhou (ORCID: https://orcid.org/0000-0002-8552-7738)
- Jianhua Zhou (ORCID: https://orcid.org/0000-0001-9895-8679)
- Kaiyuan Tan
- Jiantao Wang (ORCID: https://orcid.org/0009-0000-6071-0969)
- Yuanfang Li (ORCID: https://orcid.org/0000-0003-1762-2634)
- Zhiyong Deng (ORCID: https://orcid.org/0009-0000-4461-4491)
- Jiajun Pan
- Jinan Luo (ORCID: https://orcid.org/0009-0006-5608-951X)
- Rui Han (ORCID: https://orcid.org/0000-0002-1687-5157)
- Jianfeng Ma (ORCID: https://orcid.org/0009-0006-3968-1634)
- Dalun Rong
- Peiyan Dong (ORCID: https://orcid.org/0009-0006-4885-7742)
Institutions
- Sun Yat-sen University (CN)
- Dongguan University of Technology (CN)
- The Seventh Affiliated Hospital of Sun Yat-sen University (CN)
- Songshan Lake Materials Laboratory (CN)
- Hunan University of Technology (CN)
- Nanjing University of Aeronautics and Astronautics (CN)
- Tsinghua University (CN)
Publication Details
- Journal
- Science Advances
- Published
- 2025-12-17
- DOI
- https://doi.org/10.1126/sciadv.adz5930
- Primary Topic
- Phonocardiography and Auscultation Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00