Using a composite end-point and WIN-ratio analysis to evaluate perineal wound healing after abdominoperineal resection for rectal cancer: further insights from the BIOPEX trials
This post-hoc analysis sheds new light on perineal wound healing in randomized studies by integrating various outcome measures. Although a similar numerical advantage of the intervention was shown in both BIOPEX trials using win-ratio analysis, it only reached statistical significance for the gluteal turnover flap.
Authors
- Maarten Vermaas (ORCID: https://orcid.org/0000-0002-5006-2360)
- Robin D. Blok (ORCID: https://orcid.org/0000-0002-5291-546X)
- Cornelis Verhoef (ORCID: https://orcid.org/0000-0001-9980-8613)
- Gijsbert D. Musters (ORCID: https://orcid.org/0009-0003-1249-7587)
- Saskia I. Kreisel
- Bas Lamme
- Jacobus W. A. Burger (ORCID: https://orcid.org/0000-0003-1988-0186)
- Jarno Melenhorst (ORCID: https://orcid.org/0000-0002-1495-4003)
- Peter van Duijvendijk (ORCID: https://orcid.org/0000-0002-0441-6180)
- Roel Hompes (ORCID: https://orcid.org/0000-0001-6094-8950)
- Fatih Polat (ORCID: https://orcid.org/0000-0002-8758-8040)
- RJI Bosker
- RJCLM Vuylsteke
- Jurriaan B. Tuynman (ORCID: https://orcid.org/0000-0001-5952-8000)
- Oren Lapid (ORCID: https://orcid.org/0000-0001-8921-9866)
- J. De Wilt
- Jeroen W. A. Leijtens (ORCID: https://orcid.org/0000-0002-0807-0471)
- Andrew Van de Ven
- Joost Rothbarth
- Sarah Sharabiany (ORCID: https://orcid.org/0000-0003-2222-2037)
- Baljit Singh (ORCID: https://orcid.org/0000-0002-7987-7336)
- R. van den Berg (ORCID: https://orcid.org/0009-0001-8850-6166)
- Pieter J. Tanis (ORCID: https://orcid.org/0000-0002-3146-3310)
- Eric H J Belgers (ORCID: https://orcid.org/0000-0002-6749-4039)
- Boudewijn van Etten (ORCID: https://orcid.org/0000-0003-2900-2942)
- Sanjay Chaudhri (ORCID: https://orcid.org/0000-0002-2562-5512)
- Hans F. J. Fabry
- AAW van Geloven
- Arend G. J. Aalbers (ORCID: https://orcid.org/0000-0003-2463-6460)
- Jan H. Wijsman
- Christiaan Hoff
- Nina van Gerwen
Institutions
- University Medical Center Groningen (NL)
- Radboud University Nijmegen (NL)
- University of Groningen (NL)
- Dutch Cancer Society (NL)
- Maastricht University Medical Centre (NL)
- Gelre Hospitals (NL)
- Catharina Ziekenhuis (NL)
- Erasmus MC (NL)
- University Hospitals of Leicester NHS Trust (GB)
- Medisch Centrum Leeuwarden (NL)
- Radboud University Medical Center (NL)
- The Netherlands Cancer Institute (NL)
- Albert Schweitzer Ziekenhuis (NL)
- Amphia Ziekenhuis (NL)
- Canisius-Wilhelmina Ziekenhuis (NL)
- Zaans Medisch Centrum (NL)
- De Kinderkliniek (NL)
- Zuyderland Medisch Centrum (NL)
- IJsselland Ziekenhuis (NL)
- Tergooi (NL)
- Amsterdam University Medical Centers (NL)
- Laurentius Ziekenhuis (NL)
- Deventer Ziekenhuis (NL)
- Bravis Ziekenhuis (NL)
- Spaarne Gasthuis (NL)
- University of Amsterdam (NL)
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
Publication Details
- Journal
- International Journal of Surgery
- Published
- 2025-12-17
- DOI
- https://doi.org/10.1097/js9.0000000000004495
- Primary Topic
- Body Contouring and Surgery
- Type
- article
- Field-Weighted Citation Impact
- 0.00