Perioperative Use of Tranexamic Acid in General Surgery
This systematic review and meta-analysis found that prophylactic TXA use was associated with lower intraoperative blood loss, transfusion requirements, and major bleeding without an observed increase in thromboembolic or mortality risk. Although these findings support the use of TXA in general surgery procedures, the decision to use TXA should be individualized considering individual patient characteristics and the specific procedure being performed.
Authors
- Thiago Celestino Chulam (ORCID: https://orcid.org/0000-0002-5859-2251)
- Mayra Resende Azevedo (ORCID: https://orcid.org/0009-0004-6898-3303)
- Bernardo Fontel Pompeu (ORCID: https://orcid.org/0009-0009-2960-3810)
- Eric Pasqualotto (ORCID: https://orcid.org/0000-0002-6484-1162)
- Lucas Monteiro Delgado (ORCID: https://orcid.org/0009-0001-7687-3073)
- Sérgio Mazzola Poli de Figueiredo (ORCID: https://orcid.org/0000-0003-2986-8164)
- Gerez Martins (ORCID: https://orcid.org/0009-0006-5783-4083)
Institutions
- Universidade Federal de Minas Gerais (BR)
- University of North Carolina at Chapel Hill (US)
- Universidade Municipal de São Caetano do Sul (BR)
- AC Camargo Hospital (BR)
- Universidade Federal de Santa Catarina (BR)
- Hospital Heliópolis (BR)
- Universidade Federal do Espírito Santo (BR)
Publication Details
- Journal
- JAMA Surgery
- Published
- 2025-12-17
- DOI
- https://doi.org/10.1001/jamasurg.2025.5498
- Citations
- 2
- Primary Topic
- Blood transfusion and management
- Type
- article
- Field-Weighted Citation Impact
- 1.55