Assessment of quality of life following subtotal parathyroidectomy in patients with secondary hyperparathyroidism resulting from end-stage renal disease: a single-center prospective study in Vietnam

Patients with end-stage renal disease (ESRD), complicated by secondary hyperparathyroidism (sHPT) often experience severely impaired quality of life (QoL), for which surgery is considered the established standard of care. This study aimed to evaluate the improvement in QoL following surgery. A total of 51 patients with sHPT due to ESRD underwent subtotal parathyroidectomy at the National Hospital of Endocrinology from January to December 2024. QoL was evaluated using the Short Form-36 Health Survey (SF-36) at two intervals: prior to surgery and 3 months following surgery. The results revealed that the majority of patients experienced poor to very poor QoL prior to surgery. Factors such as dialysis duration of over 10 years and hypertension were significantly associated with reduced QoL. Postoperative outcomes demonstrated significant improvement: the mean physical health score increased from 27.88 to 44.1 points, and the mental health score improved from 31.14 to 51.19 points at 3 months post-surgery. The overall QoL score increased from 29.03 to 46.86 points, with statistically significant differences (P < 0.05). Subtotal parathyroidectomy was found to have significantly improved the QoL in patients with ESRD complicated sHPT.