Disrupted inhibin B synthesis due to Sox9 hyper-palmitoylation in Sertoli cells impairs spermatogenesis via paracrine effects
Overall, this study demonstrated that INHB synthesis can be suppressed by PA-induced hyper-palmitoylation of Sox9, and decreased secretion of INHB by Sertoli cells directly leads to spermatogenic dysfunction in the testis microenvironment. These findings highlight Sox9 palmitoylation as a candidate target for treatment of dyszoospermia accompanied with dyslipidemia, and underscore the critical role of INHB in regulating spermatogenesis within the testicular microenvironment.
Authors
- Jun Jing (ORCID: https://orcid.org/0000-0003-0877-7925)
- Yijian Xiang (ORCID: https://orcid.org/0000-0001-9069-1084)
- Xie Ge (ORCID: https://orcid.org/0000-0002-9410-5174)
- Zhaowanyue He
- Tian Du (ORCID: https://orcid.org/0000-0003-0841-6484)
- Bing Yao (ORCID: https://orcid.org/0000-0002-3420-2220)
- Jing Zhang (ORCID: https://orcid.org/0000-0001-9272-9146)
- Jiaming Shen
- Ming Zang
- Shanmeizi Zhao (ORCID: https://orcid.org/0000-0002-6435-9886)
- Kuan Liang
- Liangyu Yao
- Li Chen (ORCID: https://orcid.org/0009-0007-6683-0102)
- Li Zhou (ORCID: https://orcid.org/0000-0002-6851-8477)
- Miao Zhu
- Rujun Ma
- Yao Xu (ORCID: https://orcid.org/0000-0002-2315-0197)
Institutions
- Nanjing University of Chinese Medicine (CN)
- Jinan University (CN)
- Second Affiliated Hospital of Nanjing Medical University (CN)
- Jiangsu Province Hospital (CN)
- Dazhou Central Hospital (CN)
- Southern Medical University (CN)
- Southeast University (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Biological Research
- Published
- 2025-12-17
- DOI
- https://doi.org/10.1186/s40659-025-00661-y
- Primary Topic
- Sperm and Testicular Function
- Type
- article
- Field-Weighted Citation Impact
- 0.00