Influence of Concomitant Opioids on Difelikefalin Treatment Outcomes in Adults with Moderate-to-Severe Pruritus on Maintenance Hemodialysis: Exploratory Analyses
DFK reduced itch intensity and improved QoL, regardless of concomitant opioid use. Similar concomitant opioid-dependent safety findings were observed. With or without concomitant opioid use, DFK demonstrated considerable efficacy that improved QoL. Increased TEAEs with concomitant opioid use with either treatment suggests careful medication management is advisable.
Authors
- Thilo Schaufler (ORCID: https://orcid.org/0000-0003-1886-829X)
- James O. Burton (ORCID: https://orcid.org/0000-0003-1176-7592)
- Steven Fishbane (ORCID: https://orcid.org/0000-0002-2238-8574)
- Despina Ruessmann
- Warren Wen
- Satkiran S. Grewal
- Murray Lowe
Institutions
- University Hospitals of Leicester NHS Trust (GB)
- Vifor Pharma (Switzerland) (CH)
- Donald & Barbara Zucker School of Medicine at Hofstra/Northwell (US)
- Cara Therapeutics (United States) (US)
- Bethlehem Area School District (US)
Publication Details
- Journal
- Kidney & Blood Pressure Research
- Published
- 2025-12-17
- DOI
- https://doi.org/10.1159/000549648
- Primary Topic
- Dermatology and Skin Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00