Repeated Levonorgestrel Administration Impairs Cognitive Function via Glutamatergic Transmission and CaMKII–PKA–BDNF Signaling in the Hippocampus of Female Wistar Rats
Repeated LNG administration leads to notable cognitive deficits, likely mediated by impairments in glutamatergic signaling and downstream molecular pathways essential for synaptic plasticity. These findings underscore potential neurocognitive risks associated with prolonged LNG exposure.
Authors
- John Olabode Fatoki (ORCID: https://orcid.org/0000-0003-3246-9172)
- Adeniran Adekunle
- Benneth Ben‐Azu (ORCID: https://orcid.org/0000-0003-3569-3575)
- Noah A. Omeiza (ORCID: https://orcid.org/0000-0001-9567-9092)
- Ganiu Jimoh Akorede (ORCID: https://orcid.org/0000-0002-5410-6834)
- Aboyeji Lukuman Oyewole (ORCID: https://orcid.org/0000-0001-6777-4201)
- Oluwadamilare Iyapo (ORCID: https://orcid.org/0009-0007-3622-4136)
- Abdullateef Isiaka Alagbonsi (ORCID: https://orcid.org/0000-0002-5462-9950)
- Halimat Amin Abdulrahim (ORCID: https://orcid.org/0000-0003-3872-7419)
- Emmanuel Bukoye Oyewo
Institutions
- Lagos State University (NG)
- University of Ilorin (NG)
- University of Ibadan (NG)
- Delta State University (NG)
- Osun State University (NG)
- University of Rwanda (RW)
- Lagos State Health Service Commission (NG)
- University of Medical Sciences, Ondo
- Ladoke Akintola University of Technology (NG)
- Olusegun Agagu University of Science and Technology (NG)
Publication Details
- Journal
- Journal of Experimental Pharmacology
- Published
- 2025-12-01
- DOI
- https://doi.org/10.2147/jep.s559477
- Citations
- 1
- Primary Topic
- Menopause: Health Impacts and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.29