The basis for future personalized therapy approaches – Machine learning-generated 1-year survival rate, metastatic status and therapy-dependent survival in pancreatic cancer patients
The models developed in this study may serve as a foundation for supporting tumor board decisions and demonstrate that personalized, ML-based therapy concepts are feasible in the near future. In addition, the models proposed in this study are helpful for generating ML-based synthetic control arms in future clinical trials.
Authors
- Damian Tobias Rieke (ORCID: https://orcid.org/0000-0003-0027-7977)
- Uwe Pelzer (ORCID: https://orcid.org/0000-0001-9213-2737)
- Marcus Bahra
- Sebastian Stintzing (ORCID: https://orcid.org/0000-0002-3297-5801)
- Kristina Tschulik (ORCID: https://orcid.org/0000-0001-7637-4082)
- Markus Herbert Lerchbaumer (ORCID: https://orcid.org/0000-0003-1151-9935)
- F Schneider (ORCID: https://orcid.org/0000-0002-1452-7562)
- Matthäus Felsenstein (ORCID: https://orcid.org/0000-0003-3146-8717)
- Gregor Duwe (ORCID: https://orcid.org/0000-0001-7008-1238)
- Mihnea P. Dragomir (ORCID: https://orcid.org/0000-0002-5550-3516)
- Annabel Helga Sophie Alig (ORCID: https://orcid.org/0000-0002-3922-3450)
- Georg Hilfenhaus (ORCID: https://orcid.org/0000-0001-8764-077X)
- Ulrich Keilholz (ORCID: https://orcid.org/0000-0001-6773-9406)
- Christopher Neumann (ORCID: https://orcid.org/0009-0000-9009-8678)
- Richard G. Compton (ORCID: https://orcid.org/0000-0001-9841-5041)
- Haotian Chen (ORCID: https://orcid.org/0000-0003-1788-6605)
- Loredana Vecchione (ORCID: https://orcid.org/0000-0003-3942-5498)
- Ralf-Detlef Kutsche
Institutions
- TH Köln - University of Applied Sciences (DE)
- Johannes Gutenberg University Mainz (DE)
- Heidelberg University (DE)
- University of Michigan (US)
- Humboldt-Universität zu Berlin (DE)
- University of Oxford (GB)
- University Medical Center of the Johannes Gutenberg University Mainz (DE)
- Krankenhaus Waldfriede (DE)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
- Charité - Universitätsmedizin Berlin (DE)
- Ruhr University Bochum (DE)
Publication Details
- Journal
- European Journal of Cancer
- Published
- 2025-12-17
- DOI
- https://doi.org/10.1016/j.ejca.2025.116189
- Citations
- 1
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 1.05