Drug-Induced Partial Immunosuppression for Preclinical Human Tumor Xenograft Models
This drug-induced partial immunosuppression protocol effectively creates a reproducible state of transient immunodeficiency in outbred mice, suitable for various human tumor xenograft models. It represents a cost-effective and flexible alternative to genetic models, with the distinct advantage of preserving a residual immune microenvironment, making it particularly valuable for preclinical studies that require a partially intact host immune system.
Authors
- E. A. Pryakhin (ORCID: https://orcid.org/0000-0002-5990-9118)
- Dmitry B. Veprintsev (ORCID: https://orcid.org/0000-0002-3583-5409)
- Vladimir A. Richter (ORCID: https://orcid.org/0000-0001-5849-5892)
- Maxim V. Berezovski (ORCID: https://orcid.org/0000-0003-0514-599X)
- Natalia A. Luzan (ORCID: https://orcid.org/0009-0001-8983-5017)
- Olga S. Kolovskaya (ORCID: https://orcid.org/0000-0002-2494-2313)
- Vadim Kumeiko (ORCID: https://orcid.org/0000-0002-1639-664X)
- Anastasia A. Koshmanova (ORCID: https://orcid.org/0000-0001-7339-8660)
- Kirill A. Lukyanenko (ORCID: https://orcid.org/0000-0002-1115-6735)
- E.V. Styazhkina (ORCID: https://orcid.org/0000-0002-5481-5657)
- Elvira. S. Melikhova
- Daniil S. Grek
- А. А. Народов (ORCID: https://orcid.org/0000-0001-7384-0682)
- T.A. Garkusha (ORCID: https://orcid.org/0000-0002-3343-6973)
- Vladislav M. Farniev (ORCID: https://orcid.org/0000-0003-3346-5843)
- М. А. Дымова (ORCID: https://orcid.org/0000-0002-7281-9096)
- Evgeny V. Morozov (ORCID: https://orcid.org/0000-0003-1561-3937)
- Anna S. Kichkailo (ORCID: https://orcid.org/0000-0003-1054-4629)
- Elena V. Kuligina (ORCID: https://orcid.org/0000-0003-3145-1878)
- Tatiana N. Zamay
- Ivan I. Voronkovskii
- Anton K. Gorbushin
- Ekaterina A. Lipetskaya
- Victoriya D. Kakhanova
Institutions
- University of Ottawa (CA)
- Far Eastern Federal University (RU)
- Institute of Chemistry and Chemical Technology (RU)
- Krasnoyarsk State Medical University (RU)
- Institute of Chemical Biology and Fundamental Medicine (RU)
- Krasnoyarsk Regional Clinical Hospital (RU)
- Siberian Branch of the Russian Academy of Sciences (RU)
- A.V. Zhirmunsky National Scientific Center of Marine Biology Far Eastern Branch of the Russian Academy of Sciences (RU)
- Urals Research Center for Radiation Medicine (RU)
Publication Details
- Journal
- Cancers
- Published
- 2025-12-17
- DOI
- https://doi.org/10.3390/cancers17244025
- Primary Topic
- Cancer Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00