Multivariate Brain-Blood Signatures in Early-Stage Depression and Psychosis

In this study, early-stage depression and psychosis exhibited distinct neurobiological signatures involving immune and neuroanatomical markers, challenging fully dimensional disease models. These signatures are shaped by childhood trauma and cognition and may support biologically informed early interventions.

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Publication Details

Journal
JAMA Psychiatry
Published
2025-12-17
DOI
https://doi.org/10.1001/jamapsychiatry.2025.3803
Primary Topic
Tryptophan and brain disorders
Type
article
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article

Multivariate Brain-Blood Signatures in Early-Stage Depression and Psychosis

Joseph Kambeitz, Leonardo Fazio, Maria Nobile, Marian Surmann et al.
JAMA Psychiatry
Tryptophan and brain disorders
article

Multivariate Brain-Blood Signatures in Early-Stage Depression and Psychosis

Joseph Kambeitz, Leonardo Fazio, Maria Nobile, Marian Surmann, Otto Turtonen, Anna Toivonen, Johann Steiner, Alessandro Bertolino, Ruth Milz, Stephan Ruhrmann, María Fernanda Urquijo, Christina Andreou, Nora Penzel, Ileana Andriola, Antti Luutonen, Giuseppe Blasi, Norman Kluthausen, Ashleigh Peng Lin, Christos Pantelis, Janina Paju, Giampaolo Perna, Akseli Mäkela, Martina Wassen, Georg Romer, Sebastian von Saldern, Ifrah Khanyaree, Michael J. Ziller, Johanna Weiske, Anu Ellilä, Mirabel Pelton, Yanis Köhler, Karsten Blume, Sara Piccin, Amatya Mackintosh, Manuela Abraham, Lana Kambeitz‐Ilankovic, Dominic Dwyer, Alexandra Nikolaides, Päivi Jalo, Chris Day, Matteo Balestrieri, Paris Alexandros Lalousis, Laura Egloff, Tiziana Quarto, Raffaella Romano, Heikki Laurikainen, Alexander Denissoff, Erich Studerus, Markus Heinimaa, Giuseppe Cabras, Madalina-Octavia Buciuman, Pavan Mallikarjun, Theresa Lichtenstein, Mauro Seves, Antonia Wosgien, David Popovic, Aylin Melo, Mariam Iqbal, Carlo Altamura, Carolina Bonivento, Tiina From, Moritz Spangemacher, Giulio Pergola, Armando D’Agostino, Nathalie Kaiser, Lorenzo Del Fabro, Alessandra Alciati, Marco Garzitto, Franco Fabbro, Henri Pesonen, Frauke Schultze‐Lutter, Clara Vetter, Tuula Ilonen, Katharine Chisholm, Rachel Upthegrove, Francesca Bottinelli, Emiliano Monzani, Fabienne Harrisberger, Hans‐Jörg Wittsack, Adrian Rangnick, Maurizio Sberna, Shalaila S. Haas, Dennis M. Hedderich, Gerald Antoch, Paolo Brambilla, Olga Bienek, Elif Sarisik, Udo Dannlowski, Letizia Leanza, Claudia Lenz, Raimo K. R. Salokangas, Andrea Falsetti, Marina Sangiuliano, Sonja Widmayer, Claudius Hoff, Adele Ferro, Timo Schirmer, Stefan Borgwardt, Susanna Muckenhuber-Sternbauer, Tanja Pilgram, Peter Falkai, Camilla Krämer, Sonja Botterweck, Ana Beatriz Solana, Rachele Sanfelici, Kolja Schiltz, Dominika Julkowski, L. Neuner, Marta Re, Marco Paolini, Marika Belleri, Alexandra Stainton, Renata Smieskova, Julian Caspers, Ana Tupac, Roberta Passiatore, Siân Lowri Griffiths, Reetta-Liina Säilä, Ulrike Heitz, Nikolaos Koutsouleris, Rebekka Lencer, Stephen J. Wood, Ömer Öztürk, Nicholas M. Barnes, Anna Walter, Alkomiet Hasan, Marina Barone, Barbara Gelao, Grazia Caforio, Eva Meisenzahl, Clara Weyer
article en

Abstract

In this study, early-stage depression and psychosis exhibited distinct neurobiological signatures involving immune and neuroanatomical markers, challenging fully dimensional disease models. These signatures are shaped by childhood trauma and cognition and may support biologically informed early interventions.

JAMA PsychiatryVol. 83(2)
University of Bern (CH), Johns Hopkins University (US), University of Turku (FI), University of Sussex (GB), The University of Melbourne (AU), University of Cologne (DE), King's College London (GB), University of Milan (IT), Universitas Airlangga (ID), University of Münster (DE), Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT), Warneford Hospital (GB), University College Birmingham (GB), National Institute for Health and Care Research (GB), University of Oxford (GB), Düsseldorf University Hospital (DE), Orygen Youth Health (AU), Klinikum Magdeburg (DE), German Center for Infection Research (DE), German Centre for Cardiovascular Research (DE), Max Planck Institute of Psychiatry (DE), Clinical Research Consortium (US), Lieber Institute for Brain Development (US), Birmingham Women’s and Children’s NHS Foundation Trust (GB), Melbourne Health (AU), Heinrich Heine University Düsseldorf (DE), University of Bari Aldo Moro (IT), University of Birmingham (GB), Ludwig-Maximilians-Universität München (DE), University of Lübeck (DE), Otto-von-Guericke-Universität Magdeburg (DE)
Openalex Percentile: Top 58%
Tryptophan and brain disorders
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