Insulin-like growth factor-binding protein 3 regulates collagen production via TGF-β-Smad2/3 pathway and osteogenic differentiation related with phosphorylation of Akt in human periodontal ligament-derived cell line
IGFBP3 plays a dual role in PDL homeostasis, by promoting collagen production and inhibiting osteogenic differentiation. IGFBP3 is involved in TGF-β-Smad2/3 pathway and related with phosphorylation of Akt, highlighting IGFBP3 as a potential therapeutic target for periodontal regeneration.
Authors
- Akira Haraguchi (ORCID: https://orcid.org/0000-0002-9315-1873)
- Hiromi Mitarai (ORCID: https://orcid.org/0000-0003-3924-7863)
- Hidefumi Maeda (ORCID: https://orcid.org/0000-0002-1347-995X)
- Naohisa Wada (ORCID: https://orcid.org/0009-0000-1377-1160)
- Jiawen Lin (ORCID: https://orcid.org/0009-0003-3913-4030)
- Shuxin Wang (ORCID: https://orcid.org/0009-0005-3548-5946)
- Weihao Sun (ORCID: https://orcid.org/0000-0002-3876-2428)
- Zhi Hua Ran (ORCID: https://orcid.org/0000-0001-6388-6206)
- Asuka Yuda
- Hiroko Wada
Institutions
- Kyushu University (JP)
- Kyushu Dental University (JP)
- Kyushu University Hospital (JP)
- Fukuoka Dental College (JP)
Publication Details
- Journal
- Archives of Oral Biology
- Published
- 2025-12-17
- DOI
- https://doi.org/10.1016/j.archoralbio.2025.106483
- Primary Topic
- Growth Hormone and Insulin-like Growth Factors
- Type
- article
- Field-Weighted Citation Impact
- 0.00