Clock gene influences on sleep quality and HPA axis in major depressive disorder
These findings highlight the potential role of BMAL1 gene variants in modulating biological and clinical phenotypes related to circadian and stress regulation. The rs11022778 variant may contribute to altered sleep quality and HPA axis activity in MDD. Future research should consider such genetic markers to inform more personalized approaches to MDD treatment.
Authors
- Aida de Arriba‐Arnau (ORCID: https://orcid.org/0000-0002-7877-7341)
- Diego Palao (ORCID: https://orcid.org/0000-0002-3323-6568)
- Teresa Sagués
- Neus Salvat‐Pujol (ORCID: https://orcid.org/0000-0001-5320-331X)
- Álex Ferrer (ORCID: https://orcid.org/0000-0002-3040-1177)
- Ãngel Carracedo (ORCID: https://orcid.org/0000-0003-1085-8986)
- Javier Labad (ORCID: https://orcid.org/0000-0003-2214-1886)
- José M. Menchón (ORCID: https://orcid.org/0000-0002-6231-6524)
- Virginia Soria (ORCID: https://orcid.org/0000-0001-6412-6831)
- Javier Costas (ORCID: https://orcid.org/0000-0003-0306-3990)
- Ariadna Pelegrí
Institutions
- Instituto de Salud Carlos III (ES)
- Institut Pere Mata (ES)
- Institut d'Investigació Biomédica de Bellvitge (ES)
- Centro de Investigación Biomédica en Red de Salud Mental (ES)
- Institut de Recerca Biomèdica Catalunya Sud (ES)
- Hospital de Sabadell (ES)
- Institute of Research and Innovation Parc Tauli (ES)
- Instituto de Investigación Sanitaria de Santiago (ES)
- Servicio Gallego de Salud (ES)
- Instituto de Investigación de Enfermedades Raras (ES)
- Universitat Rovira i Virgili (ES)
Publication Details
- Journal
- Sleep Medicine
- Published
- 2025-12-17
- DOI
- https://doi.org/10.1016/j.sleep.2025.108730
- Primary Topic
- Circadian rhythm and melatonin
- Type
- article
- Field-Weighted Citation Impact
- 0.00