Distinct prognostic patterns of single hormone receptor-positive subtypes in HER2-negative breast cancer: a SEER-based retrospective cohort study

HER2-negative BC subtypes exhibit distinct survival patterns, with single HR-positive cases showing different prognosis. The present study findings may challenge conventional binary ER/PR classification and highlight ER-/PR+ as an independent high-risk factor warranting specialized therapy. The developed nomogram accurately predicted survival, underscoring the importance of clinical decision-making to optimize outcomes in HER2-negative BC patients.