Whole blood becomes increasingly susceptible to tPA-mediated fibrinolysis with storage
Stored whole blood becomes increasingly vulnerable to tPA-mediated fibrinolysis, potentially due to a combination of declining fibrinogen and platelet function. These findings raise considerations for clinical use of older whole blood units and support the potential role of adjunctive therapies during trauma resuscitation.
Authors
- Christopher D. Barrett (ORCID: https://orcid.org/0000-0001-9720-8155)
- Hunter B. Moore (ORCID: https://orcid.org/0000-0002-5939-3828)
- Collin M. White
- Aleh Bobr (ORCID: https://orcid.org/0000-0003-1597-8071)
- Flobater I. Gawargi (ORCID: https://orcid.org/0000-0003-0877-4521)
- Elizabeth R. Maginot (ORCID: https://orcid.org/0009-0008-3697-3185)
- Grace E. Volk (ORCID: https://orcid.org/0009-0003-9982-2409)
- Nancy F. Goodman
- Reynold Henry
- Nicolle K. Barmettler
- A Clegg
- Ernest E. Moore
- Trace B Moody
- Dylan C. Hiser
- Kyle S. Sextro
Institutions
- Denver Health Medical Center (US)
- Denver School of Nursing (US)
- University of Colorado Denver (US)
Publication Details
- Journal
- The Journal of Trauma: Injury, Infection, and Critical Care
- Published
- 2025-12-17
- DOI
- https://doi.org/10.1097/ta.0000000000004870
- Primary Topic
- Blood Coagulation and Thrombosis Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00