Analysis of age-specific adverse events with vancomycin: a real-world pharmacovigilance study based on the FAERS database
Real-world data from the large-scale FAERS database were used to detect vancomycin-associated adverse event signals by disproportionality analysis, Age-stratified comparisons revealed marked differences in adverse event signal. This pharmacovigilance research underscored potential safety concerns of vancomycin, corroborated known risks and identified novel safety signals not listed in the current product label. These findings expanded understanding of vancomycin's safety profile and provided evidence-based guidance for clinical practice.
Authors
- Xiang Liu (ORCID: https://orcid.org/0000-0001-6888-4525)
- Tingting Zhang (ORCID: https://orcid.org/0000-0001-9141-2593)
- Chen Wang (ORCID: https://orcid.org/0000-0003-4573-9047)
- Pei Guo
- Zujun Wen
- Peng Liu (ORCID: https://orcid.org/0009-0007-5718-3206)
Institutions
- Xiyuan Hospital (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Dazhou Central Hospital (CN)
- Chongqing Medical and Pharmaceutical College (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- International Journal of Surgery
- Published
- 2025-12-17
- DOI
- https://doi.org/10.1097/js9.0000000000004563
- Primary Topic
- Pharmacovigilance and Adverse Drug Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00