Simplified Protocol Conditions for the Gold-Catalyzed Hydrofluorination of Terminal Aliphatic Alkynes
We report, herein, a simplified protocol for the gold-catalyzed hydrofluorination of the terminal alkynes. The system employs [Au(IPr)Cl], the simplest NHC-gold complex, in a diluted HFIP/toluene solvent mixture, uses the readily available Et<sub>3</sub>N·3HF reagent, and operates without any additives.
Authors
- Nikolaos V. Tzouras (ORCID: https://orcid.org/0000-0003-1718-0207)
- Steven P. Nolan (ORCID: https://orcid.org/0000-0001-9024-2035)
- Jean‐François Paquin (ORCID: https://orcid.org/0000-0003-2412-3083)
- Claudia Gagnon (ORCID: https://orcid.org/0000-0001-9623-962X)
- Raphaël Pronovost
Institutions
- Ghent University (BE)
- Université Laval (CA)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-12-17
- DOI
- https://doi.org/10.1021/acs.joc.5c02743
- Primary Topic
- Catalytic Alkyne Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00