Surface or Luminal? Decoding Tumor Extracellular Vesicle Logic for Functional Insight and Therapeutic Reprogramming (Adv. Funct. Mater. 51/2025)
Tumor Extracellular Vesicle Logic In their Research Article (10.1002/adfm.202521108), Chi-An Cheng and co-workers introduce a nanoscale transformation, as tumor extracellular vesicles (EVs) travel from heterogeneous danger to homogeneous cure. This cover art illustrates the journey of the EV Bimodal Functional Regulator (eBFR): CLEAR purges hidden oncogenic cargo, SWITCHER isolates surface-defined EV subtypes, and eSimoa quantifies spatial protein signatures—reprogramming tumor EVs into safe, pure, and thousands-fold drug-loaded couriers for precision medicine.
Authors
- Chun‐Jung Ko (ORCID: https://orcid.org/0000-0001-6565-7060)
- Yu-Hsien Hung (ORCID: https://orcid.org/0000-0002-1963-0462)
- P. Yeh (ORCID: https://orcid.org/0000-0003-0837-1028)
- Y.F. Chen (ORCID: https://orcid.org/0000-0002-3038-4311)
- Shih‐Tang Kuo
- Shey‐Ying Chen (ORCID: https://orcid.org/0000-0002-5855-6170)
- Jhih‐Fong Li
- Chi‐An Cheng (ORCID: https://orcid.org/0000-0002-6657-9137)
- S. C. Yu
- Yu‐Syuan Chu
Institutions
- National Taiwan University (TW)
Publication Details
- Journal
- Advanced Functional Materials
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/adfm.73137
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00