Glymphatic system dysfunction mediates the relationship between deep medullary vein alterations and cognitive impairment in cerebral small vessel disease
This study suggests that DMV structural abnormalities may exacerbate CSVD-related cognitive impairment by disrupting glymphatic function. DMV scoring may serve as a potential imaging biomarker, providing a foundation for early identification and intervention.
Authors
- Songsong Zhu (ORCID: https://orcid.org/0000-0001-7593-3663)
- Ran Chen (ORCID: https://orcid.org/0000-0002-8415-7229)
- Yang Li (ORCID: https://orcid.org/0000-0002-3859-5690)
- Li Cheng (ORCID: https://orcid.org/0000-0002-8400-8813)
- Qiang Jing (ORCID: https://orcid.org/0000-0003-0510-7432)
- Wenli Lu (ORCID: https://orcid.org/0009-0008-4418-4418)
- Liya Ji
- Dan Zhou (ORCID: https://orcid.org/0000-0002-8961-5276)
Institutions
- Second Affiliated Hospital of Nanjing Medical University (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- BMC Neurology
- Published
- 2025-12-17
- DOI
- https://doi.org/10.1186/s12883-025-04535-4
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 0.00