Selective TYK2 Inhibition, Prenatal Cell Diagnostics, and Biomarker-Guided Immunotherapy: Expanding Precision Medicine

Recent innovations showcase the power of selectivity in precision medicine. Brain-penetrant TYK2 inhibitors target autoimmune and neuroinflammatory disease, fetal cell diagnostics improve prenatal screening, and biomarker signatures refine checkpoint immunotherapy. Together, these advances highlight how molecular, cellular, and patient-level selectivity drives therapeutic precision across neurology, oncology, immunology, and reproductive health, reshaping diagnostics and treatment strategies from early development through complex disease.

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Publication Details

Journal
ACS Medicinal Chemistry Letters
Published
2025-12-17
DOI
https://doi.org/10.1021/acsmedchemlett.5c00736
Primary Topic
Glioma Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
0.00
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article

Selective TYK2 Inhibition, Prenatal Cell Diagnostics, and Biomarker-Guided Immunotherapy: Expanding Precision Medicine

Mahmoud A. Elkhalifa, Robert B. Kargbo
ACS Medicinal Chemistry Letters
Glioma Diagnosis and Treatment
article

Selective TYK2 Inhibition, Prenatal Cell Diagnostics, and Biomarker-Guided Immunotherapy: Expanding Precision Medicine

Mahmoud A. Elkhalifa, Robert B. Kargbo
article en

Abstract

Recent innovations showcase the power of selectivity in precision medicine. Brain-penetrant TYK2 inhibitors target autoimmune and neuroinflammatory disease, fetal cell diagnostics improve prenatal screening, and biomarker signatures refine checkpoint immunotherapy. Together, these advances highlight how molecular, cellular, and patient-level selectivity drives therapeutic precision across neurology, oncology, immunology, and reproductive health, reshaping diagnostics and treatment strategies from early development through complex disease.

ACS Medicinal Chemistry LettersVol. 17(1)
California University of Pennsylvania (US), Usona Institute (US), University of Pennsylvania (US)
Openalex Percentile: Top 39%
Glioma Diagnosis and Treatment
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