Development of PET/CT-clinical nomograms for predicting lymph node metastasis in primary lung cancer
Question Can a nomogram integrating clinical, CT, and PET features improve preoperative prediction of lymph node metastasis in primary lung cancer, particularly in small nodes? Findings We developed a Clinical-CT-PET nomogram that achieved the best diagnostic accuracy (AUCs 0.883 and 0.877) among five models, especially for small lymph nodes (< 1 cm). Clinical relevance This noninvasive Clinical-CT-PET nomogram may improve the accuracy of preoperative lymph node staging and guide individualized treatment planning. It may also help avoid unnecessary invasive procedures in lung cancer patients, pending further multi-center validation.
Authors
- Carol C. Wu (ORCID: https://orcid.org/0000-0003-1005-0995)
- Jia Wu (ORCID: https://orcid.org/0000-0001-8392-8338)
- Don L. Gibbons (ORCID: https://orcid.org/0000-0003-2362-3094)
- Simon Heeke (ORCID: https://orcid.org/0000-0002-5916-534X)
- Brett W. Carter (ORCID: https://orcid.org/0000-0002-3841-8352)
- Lingzhi Hong (ORCID: https://orcid.org/0000-0001-6553-3279)
- Maliazurina B. Saad (ORCID: https://orcid.org/0000-0002-2895-4186)
- Julie Lin (ORCID: https://orcid.org/0000-0001-9496-9389)
- Girish S. Shroff (ORCID: https://orcid.org/0000-0001-9488-7439)
- John Victor Heymach (ORCID: https://orcid.org/0000-0001-9068-8942)
- Ara Asadur Vaporciyan (ORCID: https://orcid.org/0000-0002-2060-3584)
- Xiaoyu Han (ORCID: https://orcid.org/0009-0008-0218-8672)
- George A. Eapen (ORCID: https://orcid.org/0000-0001-6408-6964)
- Yuliya Kitsel (ORCID: https://orcid.org/0009-0001-1500-7083)
- Lauren A. Byers (ORCID: https://orcid.org/0000-0002-0780-2677)
- Jianjun Zhang (ORCID: https://orcid.org/0000-0003-2179-2388)
- Natalie I. Vokes (ORCID: https://orcid.org/0000-0002-3766-5335)
- Shuoyang Li (ORCID: https://orcid.org/0000-0001-9539-6324)
- Wentao Li
- Myrna C. B. Godoy
- Xiuning Le
- Mohamed Qayati Mohamed
Institutions
- The University of Texas MD Anderson Cancer Center (US)
Publication Details
- Journal
- European Radiology
- Published
- 2025-12-17
- DOI
- https://doi.org/10.1007/s00330-025-12166-z
- Primary Topic
- Lung Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Cancer Prevention and Research Institute of Texas
- National Institutes of Health
- University of Texas MD Anderson Cancer Center