Precision Therapeutics Across Cancer, Immunology, and Pain

Targeted protein degradation, next-generation antibody discovery, and spatial multiomics are reshaping therapeutic strategies across oncology, immunology, and neurology. Recent innovations include platelet-sparing degraders of BCL-XL for cancer treatment, rare antibody recovery platforms for challenging antigens, in situ sequencing for immune repertoire mapping, and senolytic PROTACs that target pain-associated neurons. Together, these approaches exemplify how mechanistic precision and synergistic platforms can accelerate therapeutic breakthroughs.

Authors

Institutions

Publication Details

Journal
ACS Medicinal Chemistry Letters
Published
2025-12-17
DOI
https://doi.org/10.1021/acsmedchemlett.5c00735
Primary Topic
Protein Degradation and Inhibitors
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Precision Therapeutics Across Cancer, Immunology, and Pain

Mahmoud A. Elkhalifa, Robert B. Kargbo
ACS Medicinal Chemistry Letters
Protein Degradation and Inhibitors
article

Precision Therapeutics Across Cancer, Immunology, and Pain

Mahmoud A. Elkhalifa, Robert B. Kargbo
article en

Abstract

Targeted protein degradation, next-generation antibody discovery, and spatial multiomics are reshaping therapeutic strategies across oncology, immunology, and neurology. Recent innovations include platelet-sparing degraders of BCL-XL for cancer treatment, rare antibody recovery platforms for challenging antigens, in situ sequencing for immune repertoire mapping, and senolytic PROTACs that target pain-associated neurons. Together, these approaches exemplify how mechanistic precision and synergistic platforms can accelerate therapeutic breakthroughs.

ACS Medicinal Chemistry LettersVol. 17(1)
California University of Pennsylvania (US), Usona Institute (US), University of Pennsylvania (US)
Openalex Percentile: Top 63%
Protein Degradation and Inhibitors
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.