Precision Therapeutics Across Cancer, Immunology, and Pain
Targeted protein degradation, next-generation antibody discovery, and spatial multiomics are reshaping therapeutic strategies across oncology, immunology, and neurology. Recent innovations include platelet-sparing degraders of BCL-XL for cancer treatment, rare antibody recovery platforms for challenging antigens, in situ sequencing for immune repertoire mapping, and senolytic PROTACs that target pain-associated neurons. Together, these approaches exemplify how mechanistic precision and synergistic platforms can accelerate therapeutic breakthroughs.
Authors
- Mahmoud A. Elkhalifa
- Robert B. Kargbo (ORCID: https://orcid.org/0000-0002-5539-6343)
Institutions
- California University of Pennsylvania (US)
- Usona Institute (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- ACS Medicinal Chemistry Letters
- Published
- 2025-12-17
- DOI
- https://doi.org/10.1021/acsmedchemlett.5c00735
- Primary Topic
- Protein Degradation and Inhibitors
- Type
- article
- Field-Weighted Citation Impact
- 0.00