Zoledronate and Clodronate affecting bone repair in non-critical defects grafted with carbonated nanostructured hydroxyapatite: an in vivo study fostering clinical reasoning
Both bisphosphonates enhanced bone repair in the femoral defect model, demonstrating a synergistic effect when combined with nanostructured CHA. Zoledronate required the presence of the biomaterial to exert its osteogenic influence, while Clodronate stimulated new bone formation independently. These findings indicate that generation-specific differences among bisphosphonates may guide their future use in bone tissue engineering strategies.
Authors
- José Mauro Granjeiro (ORCID: https://orcid.org/0000-0002-8027-8293)
- Mônica Diuana Calasans‐Maia (ORCID: https://orcid.org/0000-0001-5759-7926)
- Gutemberg Gomes Alves (ORCID: https://orcid.org/0000-0003-0016-4809)
- Adriana Terezinha Neves Novellino Alves (ORCID: https://orcid.org/0000-0002-3665-6568)
- Alexandre Malta Rossi (ORCID: https://orcid.org/0000-0003-4244-8455)
- Carlos Rodrigues Pereira (ORCID: https://orcid.org/0000-0003-4000-4324)
Institutions
- Universidade Federal Fluminense (BR)
- Instituto Nacional de Metrologia, Qualidade e Tecnologia (BR)
- Centro Brasileiro de Pesquisas Físicas (BR)
- A.T. Still University (US)
Publication Details
- Journal
- Biomaterial Investigations in Dentistry
- Published
- 2025-12-17
- DOI
- https://doi.org/10.2340/biid.v12.45131
- Primary Topic
- Bone health and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00