High BRAF variant allele frequency predicts poor outcomes in metastatic melanoma patients treated with BRAF/MEK inhibitors
Our study demonstrated the role of the BRAF-VAF as predictor of response in MM patients treated with BRAF/MEK inhibitors. Moreover, VAF normalization predicts PFS better than BRAF-VAF alone.
Authors
- Michele Del Vecchio (ORCID: https://orcid.org/0000-0001-9060-2512)
- Alice Indini (ORCID: https://orcid.org/0000-0001-8686-4106)
- Benedetta Apollonio (ORCID: https://orcid.org/0000-0003-2414-5549)
- Stefania Pellegrini (ORCID: https://orcid.org/0000-0001-5198-5901)
- Marco Tucci (ORCID: https://orcid.org/0000-0003-4008-4897)
- M. Lombardo (ORCID: https://orcid.org/0000-0002-9502-5133)
- Elisa Melucci (ORCID: https://orcid.org/0000-0003-4908-5271)
- Raffaele Conca (ORCID: https://orcid.org/0000-0003-0683-5474)
- Enrica T. Tanda (ORCID: https://orcid.org/0000-0002-1552-9826)
- Cristina Pellegrini (ORCID: https://orcid.org/0000-0003-2168-8097)
- Rebecca Senetta (ORCID: https://orcid.org/0000-0001-8419-4591)
- Maria Chiara Scaini (ORCID: https://orcid.org/0000-0002-9583-3034)
- Maria Teresa Maccallini (ORCID: https://orcid.org/0000-0002-8120-9126)
- Simona De Summa (ORCID: https://orcid.org/0000-0001-9607-3754)
- Piergiorgio Di Tullio
- Teresa Troiani
- Elena Croce (ORCID: https://orcid.org/0000-0002-2343-144X)
- Mary Macri
- Michele Guida (ORCID: https://orcid.org/0000-0001-8411-0319)
- Francesco Spagnolo (ORCID: https://orcid.org/0000-0003-3287-1225)
- S. Brugnara
- Livia Fucci (ORCID: https://orcid.org/0000-0002-4096-7211)
- Pietro Quaglino (ORCID: https://orcid.org/0000-0003-4185-9586)
- Fabiana Perrone (ORCID: https://orcid.org/0000-0001-8090-770X)
- Paolo Fava (ORCID: https://orcid.org/0000-0002-8443-7458)
- Roberta Depenni
- Sabino Strippoli (ORCID: https://orcid.org/0000-0001-7982-7788)
- Paola Queirolo (ORCID: https://orcid.org/0000-0002-9917-6633)
- Salvatore Girlando
- Iole Natalicchio
- Alessandro Marco Minisini (ORCID: https://orcid.org/0000-0001-7712-7286)
- Giuseppe Pugliese (ORCID: https://orcid.org/0000-0003-4170-6424)
- Silvia Costabile
- Teresa Squicciarini
- Luca Romano
- Rosamaria Pinto
- Francesco Caraglia (ORCID: https://orcid.org/0009-0000-1853-9897)
Institutions
- University of Foggia (IT)
- University of Parma (IT)
- University of Campania "Luigi Vanvitelli" (IT)
- University of L'Aquila (IT)
- University of Perugia (IT)
- Oncology Group of Southern Italy (IT)
- Ospedale Santa Chiara (IT)
- Centro di Riferimento Oncologico della Basilicata (IT)
- Azienda Ospedaliero-Universitaria di Modena (IT)
- Istituto Oncologico Veneto (IT)
- Ospedale Santa Maria della Misericordia di Udine (IT)
- Istituto Tumori Bari (IT)
- National Cancer Institute (MY)
- Ospedale Policlinico San Martino (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
- Aziende Socio Sanitarie Territoriale dei Sette Laghi
- University of Turin (IT)
- University of Bari Aldo Moro (IT)
- European Institute of Oncology (IT)
- University of Genoa (IT)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-12-17
- DOI
- https://doi.org/10.1186/s12967-025-07434-x
- Primary Topic
- Melanoma and MAPK Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministero della Salute