Functional Outcomes Across High-Risk OCT-Based Phenotypes in Intermediate Age-Related Macular Degeneration—PINNACLE Study Report 11
Integrating comprehensive analyses of structural OCT biomarkers with functional assessments revealed distinct phenotypic subtypes of iAMD that are associated with significant functional deficits. Particularly, early atrophy markers should be considered for patient selection and risk assessment in clinical trials and routine practice.
Authors
- Martin J. Menten (ORCID: https://orcid.org/0000-0001-8261-7810)
- Lars G. Fritsche (ORCID: https://orcid.org/0000-0002-2110-1690)
- Daniel Rueckert (ORCID: https://orcid.org/0000-0002-5683-5889)
- Maximilian Pfau (ORCID: https://orcid.org/0000-0001-9761-9640)
- Stefan Sacu (ORCID: https://orcid.org/0000-0002-4920-2231)
- Sophie Riedl (ORCID: https://orcid.org/0000-0003-0003-0886)
- Julia Mai (ORCID: https://orcid.org/0000-0002-0528-9742)
- Hendrik P. N. Scholl (ORCID: https://orcid.org/0000-0002-7312-0316)
- Sobha Sivaprasad (ORCID: https://orcid.org/0000-0001-8952-0659)
- Andrew Lotery (ORCID: https://orcid.org/0000-0001-5541-4305)
- A Toby Prevost (ORCID: https://orcid.org/0000-0003-1723-0796)
- Hrvoje Bogunović (ORCID: https://orcid.org/0000-0002-9168-0894)
- Ursula Schmidt-Erfurth
- Marie Louise Enzendorfer
Institutions
- Austrian Research Institute for Artificial Intelligence (AT)
- University of Basel (CH)
- University of Michigan (US)
- Michigan United (US)
- Department of Biomedicine Basel (CH)
- European Society of Clinical Microbiology and Infectious Diseases (CH)
- Moorfields Eye Hospital (GB)
- Institute of Molecular and Clinical Ophthalmology Basel (CH)
- University of Southampton (GB)
- University College London (GB)
- Imperial College London (GB)
- Technical University of Munich (DE)
- Medical University of Vienna (AT)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-12-17
- DOI
- https://doi.org/10.1167/iovs.66.15.54
- Primary Topic
- Retinal Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00