“The RAS Dam Has Broken”

ASP3082, a proteolysis targeting chimera that targets mutant KRASG12D, and elironrasib, a tri-complex inhibitor of KRASG12C in the "on" state, showed encouraging efficacy and safety in separate phase I trials.

Publication Details

Journal
Cancer Discovery
Published
2025-12-05
DOI
https://doi.org/10.1158/2159-8290.cd-nw2025-0108
Primary Topic
Protein Kinase Regulation and GTPase Signaling
Type
article
Field-Weighted Citation Impact
0.00
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article

“The RAS Dam Has Broken”

Cancer Discovery
Protein Kinase Regulation and GTPase Signaling
article

“The RAS Dam Has Broken”

article en

Abstract

ASP3082, a proteolysis targeting chimera that targets mutant KRASG12D, and elironrasib, a tri-complex inhibitor of KRASG12C in the "on" state, showed encouraging efficacy and safety in separate phase I trials.

Cancer DiscoveryVol. 16(1)
Openalex Percentile: Top 63%
Protein Kinase Regulation and GTPase Signaling
DOISourceOpenAlex
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“The RAS Dam Has Broken” · Cancer Discovery (2025) | TGRS Research Map | TGRS