Multi-Components in Modified Tongyou Decoction Targeting Akt/mTOR to Modulate Esophageal Cancer Cell Autophagy via Network Pharmacology Integrated with Experimental Verification
MTD specifically promotes EC autophagy depending on multiple components and specifically targets Akt/mTOR signaling pathway. MTD shows clear activity in EC cell autophagy regulated by the Akt/mTOR pathway.
Authors
- Yongsen Jia (ORCID: https://orcid.org/0000-0002-8305-2273)
- Jing Zhang (ORCID: https://orcid.org/0000-0002-0313-6857)
- Gabriella Hegyi (ORCID: https://orcid.org/0000-0002-0620-7892)
- Xin Yan (ORCID: https://orcid.org/0009-0001-6789-2045)
- Lingyu Kong (ORCID: https://orcid.org/0000-0002-1216-2432)
- Yingying Tian
- Yueyue Yu (ORCID: https://orcid.org/0009-0006-7354-6321)
- Wenli Zhang (ORCID: https://orcid.org/0000-0002-4989-7950)
- Andras Csaszi (ORCID: https://orcid.org/0009-0009-0128-2269)
Institutions
- North China University of Science and Technology (CN)
- North China University of Science and Technology Affiliated Hospital (CN)
- University of Pecs (HU)
Publication Details
- Journal
- Clinical and Experimental Gastroenterology
- Published
- 2025-12-01
- DOI
- https://doi.org/10.2147/ceg.s560771
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.00