Geographic Variability in Germline Genetic Testing for Prostate Cancer: A Nationwide Medicare Claims Study With Evidence of Low Uptake
This study reveals substantial underutilization of germline genetic testing among Medicare beneficiaries with prostate cancer. Despite evidence supporting its use and benefits, <3% of patients underwent testing, even though more than one-third met established criteria. These findings underscore the need to improve regional access to testing and increase awareness among patients and physicians, particularly for older and Asian populations.
Authors
- Caroline M. Moore (ORCID: https://orcid.org/0000-0003-0202-7912)
- Zhiyu Qian
- Stephan Korn
- Jianyi Zhang (ORCID: https://orcid.org/0000-0002-3955-6554)
- Stacy Loeb (ORCID: https://orcid.org/0000-0003-3933-9207)
- Klara K. Pohl
- Kerry L. Kilbridge (ORCID: https://orcid.org/0000-0001-7460-6273)
- Hanna Zurl
- Adam S. Kibel (ORCID: https://orcid.org/0000-0002-9446-7781)
- Veda N. Giri (ORCID: https://orcid.org/0000-0002-7268-5913)
- Stuart R. Lipsitz (ORCID: https://orcid.org/0000-0003-2619-1389)
- Shahrokh François Shariat (ORCID: https://orcid.org/0000-0002-6627-6179)
- Alexander P. Cole (ORCID: https://orcid.org/0000-0002-0049-8529)
- Huma Q. Rana (ORCID: https://orcid.org/0000-0002-1598-6752)
- Andrea Piccolini (ORCID: https://orcid.org/0009-0004-6601-1244)
- Quoc-Dien Trinh (ORCID: https://orcid.org/0009-0002-6752-0388)
Institutions
- Brigham and Women's Hospital (US)
- Humanitas University (IT)
- Harvard University (US)
- University of Pittsburgh (US)
- Medical University of Graz (AT)
- Yale Cancer Center (US)
- Massachusetts General Hospital (US)
- Dana-Farber Cancer Institute (US)
- Cancer Genetics (United States) (US)
- Karl Landsteiner Society (AT)
- University College London (GB)
- New York University (US)
- Medical University of Vienna (AT)
Publication Details
- Journal
- Journal of the National Comprehensive Cancer Network
- Published
- 2025-12-01
- DOI
- https://doi.org/10.6004/jnccn.2025.7074
- Primary Topic
- BRCA gene mutations in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00