Metal-free halogen atom transfer for carbocyclization of <i>N</i> -arylacrylamides enabled by visible light-excited ligated boryl radicals
A visible light-induced, metal-free method for synthesizing 3,3-dialkylated oxindoles <i>via</i> boryl radical-mediated halogen atom transfer is described. This approach enables the carbocyclization of <i>N</i>-arylacrylamides under ambient air using an organic photosensitizer and NHC-BH<sub>3</sub>, to accommodate both alkyl and aryl halides. The practicality of this protocol is demonstrated through facile scalability and applications in drug synthesis.
Authors
- Zhihong Qiu
- Hongming Jin (ORCID: https://orcid.org/0000-0002-5509-5436)
- Bin Dong (ORCID: https://orcid.org/0000-0002-1980-8929)
- Cao Tao
- Yuxia Dai
- Wanping Zheng
Institutions
- Nanjing University of Chinese Medicine (CN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-12-17
- DOI
- https://doi.org/10.1039/d5cc06403a
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00