Electroacupuncture Potentiates Astragaloside IV Cerebral Delivery via P‐Glycoprotein‐Mediated Transcellular Transport: A Novel Blood–Brain Barrier Penetration Strategy for Ischemic Stroke Therapy
These findings indicate that EA enhances the brain uptake and neuroprotective effects of AS-IV, irrespective of BBB integrity. The underlying mechanism involves P-gp-mediated transcellular transport rather than the paracellular pathway.
Authors
- Yao‐Hsu Yang (ORCID: https://orcid.org/0000-0002-6266-9864)
- Shuping Fu (ORCID: https://orcid.org/0000-0002-4047-9330)
- Xiaolong Zhang (ORCID: https://orcid.org/0000-0001-7713-7193)
- Qidong Huang (ORCID: https://orcid.org/0000-0003-2702-8516)
- Ling OuYang
- Yi Cao (ORCID: https://orcid.org/0000-0002-4222-8439)
- Xiaogang Hao (ORCID: https://orcid.org/0000-0001-9826-3914)
- Bufan Wu
- Jingjing Zhang (ORCID: https://orcid.org/0000-0002-7953-1159)
- Ying Chen (ORCID: https://orcid.org/0000-0001-9758-7116)
- Sheng-Feng Lu (ORCID: https://orcid.org/0000-0001-5600-0999)
- Yonglin Chen (ORCID: https://orcid.org/0000-0001-9306-4043)
- Xinyi Yang (ORCID: https://orcid.org/0000-0002-6732-7492)
- Xinyue Jing (ORCID: https://orcid.org/0000-0002-2969-6094)
- Jie Wu (ORCID: https://orcid.org/0000-0002-7806-6718)
Institutions
- Hebei Medical University (CN)
- Nanjing University of Chinese Medicine (CN)
- China Pharmaceutical University (CN)
- Jiujiang First People's Hospital (CN)
Publication Details
- Journal
- Brain and Behavior
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/brb3.71134
- Primary Topic
- Traditional Chinese Medicine Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Government of Jiangsu Province
- Nanjing University of Chinese Medicine
- Nanjing University
- Key University Science Research Project of Jiangsu Province