Consideration of sex as a biological variable over the history of the 5xFAD Alzheimer’s Disease mouse model
The 5xFAD model represents a compelling example of how neglecting to recognize the impact of biological sex on neural function can compromise study design and data interpretation. Given sex-dependent Thy1 promoter regulation may skew phenotypic outcomes, investigators should judiciously interpret sex differences observed in any AD mouse utilizing the Thy1 promoter to drive transgene expression.
Authors
- H. T. Edwards (ORCID: https://orcid.org/0000-0001-5121-8972)
- Adele Stewart (ORCID: https://orcid.org/0000-0003-4968-2471)
- Kimberly Hernandez
- Julia I. Neuharth
- Jacob Bernholtz
Institutions
- University of Iowa (US)
- Florida Atlantic University (US)
Publication Details
- Journal
- Biology of Sex Differences
- Published
- 2025-12-17
- DOI
- https://doi.org/10.1186/s13293-025-00788-3
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Brain and Behavior Research Foundation
- National Alliance for Research on Schizophrenia and Depression
- National Institutes of Health