Antimicrobial resistance, virulence defects, and evolutionary dynamics of multidrug-resistant <i>Klebsiella pneumoniae</i> from human and animal hosts in Central China
MDR <i>K. pneumoniae</i> strains (ST35, ST101, and ST592) from animal hosts show genomic linkage to clinical human isolates, signaling interspecies transmission risks. The attenuated virulence of the ST11-KL64 is attributed to ISKpn26-mediated suppression of <i>rmpA</i> expression, a key regulator of hypervirulence in <i>K. pneumoniae</i>.
Authors
- Wen Sun (ORCID: https://orcid.org/0009-0002-3861-7850)
- Xiaoman Zhu
- Baojing Dou
- Qian Guo (ORCID: https://orcid.org/0000-0002-8622-8553)
- Yulian Wang (ORCID: https://orcid.org/0000-0003-1589-0125)
- Xiangyun Wu
- Xiaomin Pang
- Linshen Li
Institutions
- Huazhong Agricultural University (CN)
- China Animal Disease Control Center (CN)
- Taiwan Centers for Disease Control (TW)
Publication Details
- Journal
- Microbiology Spectrum
- Published
- 2025-12-17
- DOI
- https://doi.org/10.1128/spectrum.02269-25
- Citations
- 1
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.59