Feasibility and Safety of Aerosolized Influenza Virus Challenge in Humans Using Two Modern Delivery Systems
In this small pilot, aerosolized challenge using modern delivery systems was feasible under controlled conditions; no safety concerns were identified, and MMID was induced in a subset of participants. These data establish a methodological framework for future studies evaluating pathogenesis and mucosal immune responses to a variety of respiratory pathogens.
Authors
- Seema S. Lakdawala (ORCID: https://orcid.org/0000-0002-7679-2150)
- Linsey C. Marr (ORCID: https://orcid.org/0000-0003-3628-6891)
- Colleen S. Kraft (ORCID: https://orcid.org/0000-0003-1757-8477)
- A. J. Campbell (ORCID: https://orcid.org/0000-0003-4780-0227)
- Mikhael F. El‐Chami (ORCID: https://orcid.org/0000-0003-4978-7177)
- Matthew D. Pauly (ORCID: https://orcid.org/0000-0001-6710-7142)
- Jessica Traenkner
- Shamika Danzy (ORCID: https://orcid.org/0000-0002-7261-4146)
- Nishit Shetty (ORCID: https://orcid.org/0000-0002-0488-7716)
- Anice C. Lowen (ORCID: https://orcid.org/0000-0002-9829-112X)
- Hanh Nguyen
- Alexandra Longest (ORCID: https://orcid.org/0000-0001-8463-7532)
- Danielle Gulick (ORCID: https://orcid.org/0000-0002-5052-780X)
- Nadine Rouphael (ORCID: https://orcid.org/0000-0002-2512-7919)
- Joshua F. Detelich (ORCID: https://orcid.org/0000-0002-8585-0594)
- Jin Pan (ORCID: https://orcid.org/0000-0001-8699-2394)
- Aneesh K. Mehta (ORCID: https://orcid.org/0000-0002-6552-9162)
- Cecilia Zhang
- Michelle N. Vu (ORCID: https://orcid.org/0000-0002-3208-710X)
- Veronica Smith (ORCID: https://orcid.org/0000-0003-1533-7207)
- Matthew Gaddy (ORCID: https://orcid.org/0000-0002-3219-436X)
- Grace Quirk
- Eric C. Fitts (ORCID: https://orcid.org/0000-0001-6632-2246)
- Kaitlyn Bushfield
- Kayle Patatanian (ORCID: https://orcid.org/0009-0005-5878-9133)
- Alex Mann
- Andrew Catchpole
- Meredith J. Shephard (ORCID: https://orcid.org/0000-0003-4035-6653)
- Ralph Tanios
- Christelle Radi (ORCID: https://orcid.org/0009-0005-4234-0673)
- Kayla Brizuela
- Nahara Vargas-Maldonado (ORCID: https://orcid.org/0000-0001-7150-0369)
Institutions
- University of Iowa (US)
- University of Kansas (US)
- Emory University (US)
- hVIVO (United Kingdom) (GB)
- HOPE Clinic (US)
- Pulmonary and Allergy Associates (US)
- Iowa Department of Public Health (US)
- University of Iowa Health Care (US)
- Virginia Tech (US)
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2025-12-05
- DOI
- https://doi.org/10.1093/infdis/jiaf603
- Primary Topic
- Inhalation and Respiratory Drug Delivery
- Type
- article
- Field-Weighted Citation Impact
- 0.00