Tumor Necrosis Factor Inhibitor Therapy Increases Absolute Lymphocyte Count and Is Associated With Lower Mortality in Patients With Psoriatic Arthritis
TNFi therapy increases the peripheral blood ALC in patients with PsA, and this is associated with lower subsequent mortality. Mechanisms underlying this relationship may include effects of PsA, TNFi, and IL-6 on T cell subset homeostasis.
Authors
- Carey L. Shive (ORCID: https://orcid.org/0000-0002-6908-1246)
- Eric J. Hall (ORCID: https://orcid.org/0000-0003-4564-657X)
- Laura Silversteyn
- Donald D. Anthony (ORCID: https://orcid.org/0000-0002-1226-5976)
- Sabine Behrens (ORCID: https://orcid.org/0000-0002-9714-104X)
- Hinnah Siddiqui
- Maya Mattar
- Brigid Wilson (ORCID: https://orcid.org/0000-0003-2966-2940)
- Megan L. O’Mara (ORCID: https://orcid.org/0000-0002-8764-1585)
- Mahesha Makandura
- Shahdi K. Malakooti (ORCID: https://orcid.org/0000-0001-7534-2134)
- Vicky Nahra (ORCID: https://orcid.org/0000-0003-0061-2835)
- Angela D. Gupta (ORCID: https://orcid.org/0000-0002-0426-8632)
- David A. Zidar (ORCID: https://orcid.org/0000-0002-2805-3986)
- Lenche Kostadinova
- Jemima Brittlebank
Institutions
- MetroHealth (US)
- VA Northeast Ohio Healthcare System (US)
- University School (US)
- Case Western Reserve University (US)
Publication Details
- Journal
- ACR Open Rheumatology
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/acr2.70135
- Primary Topic
- Spondyloarthritis Studies and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00