Incidence and Risk Factors of QT Prolongation and Torsades de Pointes following Intravenous Amiodarone Administration for Atrial Fibrillation: A Cohort Study.

Although the incidence of QTc interval prolongation and TdP related to intravenous amiodarone therapy in patients with AF was relatively low, the risk was significantly elevated in individuals with diabetes mellitus, a history of stroke, or concurrent use of antipsychotic or anticholinergic agents. These findings underscore the importance of vigilant risk assessment and monitoring in clinical practice to mitigate the potential for intravenous amiodarone-induced arrhythmic complications.