Non-gestational choriocarcinomas in postmenopausal period
Non-gestational choriocarcinomas (NGCCs) are extremely rare and aggressive tumours that can develop without pregnancy. We present three cases in postmenopausal women in their early 60s and 70s who presented with abdominal symptoms. Evaluation included imaging, histopathology, immunohistochemistry and elevated serum β-hCG. One patient showed a partial response to chemotherapy, while two had disease progression and died. The case series illustrates the need for consideration of NGCC in older women with elevated β-hCG and no recent pregnancy, and the crucial role of early immunohistochemical diagnosis.
Authors
- Dharmishtha Basu (ORCID: https://orcid.org/0000-0003-1602-0543)
- Varun Goel (ORCID: https://orcid.org/0000-0003-3590-3261)
- Vineet Talwar (ORCID: https://orcid.org/0000-0001-9149-6969)
- Arpit Jain (ORCID: https://orcid.org/0000-0002-3916-4411)
- Nivedita Patnaik (ORCID: https://orcid.org/0000-0002-9770-1246)
- Aakanksha Jaju
Institutions
- Vardhman Mahavir Medical College & Safdarjung Hospital (IN)
- Max Super Speciality Hospital (IN)
- Rajiv Gandhi Cancer Institute and Research Centre (IN)
- Bhagwan Mahaveer Cancer Hospital and Research Centre (IN)
- BLK Super Speciality Hospital (IN)
Publication Details
- Journal
- BMJ Case Reports
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1136/bcr-2025-268341
- Primary Topic
- Gestational Trophoblastic Disease Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00