Reductive deoxygenation of tertiary alcohols: a cobalt-catalyzed hydrosilylation approach
Dehydrogenation of tertiary alcohols is both highly challenging and of notable importance in synthetic chemistry. We report a readily available Co<sub>2</sub>(CO)<sub>8</sub> catalyzed hydrosilylation protocol for the reductive deoxygenation of tertiary alcohols involving a radical mechanism. Successful deoxygenation of various tertiary, secondary and primary alcohols demonstrated the broad applicability, including syntheses of fine chemicals. A plausible mechanistic path was proposed based on several control experiments.
Authors
- Sukadev Meher (ORCID: https://orcid.org/0000-0003-4397-3139)
- R.K. Swain (ORCID: https://orcid.org/0000-0001-6040-1074)
- Bidraha Bagh (ORCID: https://orcid.org/0000-0003-0489-3312)
- Braja Kishore Marndi
Institutions
- National Institute of Science Education and Research (IN)
- Homi Bhabha National Institute (IN)
Publication Details
- Journal
- Organic & Biomolecular Chemistry
- Published
- 2025-12-08
- DOI
- https://doi.org/10.1039/d5ob01788b
- Primary Topic
- Asymmetric Hydrogenation and Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute of Science Education and Research
- Science and Engineering Research Board