Leprosy reactions beyond the textbook: a case series of uncommon manifestations

Abstract Leprosy is a chronic infectious disease caused by Mycobacterium leprae, which affects the skin and peripheral nerves. Despite being declared eliminated as a public health problem globally in 2000, atypical presentations can still pose diagnostic challenges, leading to delayed treatment and complications. This case series highlights unusual clinical presentations of leprosy to emphasize the importance of vigilance and timely diagnosis, even in the post-elimination era. Three patients with varied and atypical dermatological manifestations of leprosy were evaluated. Uncommon presentations of leprosy highlight the need for heightened awareness and early diagnostic tools to prevent morbidity and transmission.