Detecting the Cure Model Appropriateness in Randomized Clinical Trials With Long-Term Survivors
When analyzing survival data from RCTs, the appropriateness of a cure model could be considered in the face of a plateau shape of the survival curves. To ensure that the presence of such a plateau in the survival curves is a reliable indicator of the presence of cured patients in the population, the RECeUS method should be used in each randomized arm separately, with criteria met in at least one randomized arm.
Authors
- Megan Othus (ORCID: https://orcid.org/0000-0001-8176-6371)
- Sylvie Chevret (ORCID: https://orcid.org/0000-0001-6449-4730)
- Subodh Selukar (ORCID: https://orcid.org/0000-0002-3802-488X)
- Cheryl Kouadio (ORCID: https://orcid.org/0009-0000-6200-1234)
Institutions
- St. Jude Children's Research Hospital (US)
- Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa (ZA)
- Inserm (FR)
- Institut Universitaire de France (FR)
- Université Paris Cité (FR)
- Fred Hutch Cancer Center (US)
- École Nationale de la Statistique et de l'Analyse de l'Information (FR)
- Hôpital Saint-Louis (FR)
- ENSAE Paris (FR)
Publication Details
- Journal
- JCO Clinical Cancer Informatics
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1200/cci-25-00084
- Primary Topic
- Advanced Causal Inference Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00