Stroke in paediatric Crohn’s disease

Neurological complications in inflammatory bowel disease are rare but can increase morbidity. The risk is higher in poorly controlled disease with recurrent flare-ups.We discuss an adolescent girl with difficult-to-treat Crohn's disease (CD) complicated by haemorrhagic stroke. While she was under treatment for an episode of flare-up, she developed haemiparesis, facial nerve palsy and focal seizures. In the past, she had experienced multiple admissions for recurrent abdominal pain and altered bowel habits. A thorough evaluation confirmed the diagnosis of CD. Though her disease status required administration of biologicals in the initial phase, due to financial constraints, it was not possible. In the present admission for a relapse, she developed a stroke. Neuroimaging with angiography suggested infarction with haemorrhagic transformation in the left posterior parietal lobe and thrombosis of the superior sagittal sinus and left transverse sinus.Emergency stabilisation was done with antiepileptics and anticoagulants. She was initiated on infliximab during the rehabilitation phase. The primary disease is under partial remission, and facial and limb weaknesses have recovered completely.

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Publication Details

Journal
BMJ Case Reports
Published
2025-12-01
DOI
https://doi.org/10.1136/bcr-2025-269145
Primary Topic
Inflammatory Bowel Disease
Type
article
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article

Stroke in paediatric Crohn’s disease

Seema Pavaman Sindgikar, Dergham Majeed Hameed, Chandrashekar J Sorake, Sai Anjali Kambala
BMJ Case Reports
Inflammatory Bowel Disease
article

Stroke in paediatric Crohn’s disease

Seema Pavaman Sindgikar, Dergham Majeed Hameed, Chandrashekar J Sorake, Sai Anjali Kambala
article en

Abstract

Neurological complications in inflammatory bowel disease are rare but can increase morbidity. The risk is higher in poorly controlled disease with recurrent flare-ups.We discuss an adolescent girl with difficult-to-treat Crohn's disease (CD) complicated by haemorrhagic stroke. While she was under treatment for an episode of flare-up, she developed haemiparesis, facial nerve palsy and focal seizures. In the past, she had experienced multiple admissions for recurrent abdominal pain and altered bowel habits. A thorough evaluation confirmed the diagnosis of CD. Though her disease status required administration of biologicals in the initial phase, due to financial constraints, it was not possible. In the present admission for a relapse, she developed a stroke. Neuroimaging with angiography suggested infarction with haemorrhagic transformation in the left posterior parietal lobe and thrombosis of the superior sagittal sinus and left transverse sinus.Emergency stabilisation was done with antiepileptics and anticoagulants. She was initiated on infliximab during the rehabilitation phase. The primary disease is under partial remission, and facial and limb weaknesses have recovered completely.

BMJ Case ReportsVol. 18(12)
K S Hegde Medical Academy (IN)
Openalex Percentile: Top 57%
Inflammatory Bowel Disease
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