Preserved cognitive–functional phenotype in centenarians and its association with modifiable risk factors for dementia: Results from the Colombian centenarians project
Dementia risk factors act differently in Colombian centenarians. Frailty and malnutrition strongly linked to dementia in centenarians. Preserved cognitive-functional phenotype identified in 36% of centenarians. Quality of life and physical performance protect against cognitive decline. Classical risk factors (education, hypertension, diabetes) showed no effect.
Authors
- Ivan David Lozada‐Martínez (ORCID: https://orcid.org/0000-0002-1960-7334)
- Sandra Milena Castelblanco Toro (ORCID: https://orcid.org/0000-0003-0368-0577)
- Juan‐Manuel Anaya (ORCID: https://orcid.org/0000-0002-6444-1249)
- Hernan Felipe Guillen-Burgos (ORCID: https://orcid.org/0000-0003-1835-431X)
- Juan Carlos Salazar (ORCID: https://orcid.org/0000-0003-2286-3627)
Institutions
- Pontificia Universidad Javeriana (CO)
- Universidad Nacional de Colombia (CO)
- University of the Coast (CO)
- Universidad Simón Bolívar (CO)
- Hospital Universitario San Ignacio (CO)
- Universidad Autónoma de Colombia (CO)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz.71034
- Citations
- 1
- Primary Topic
- Genetics, Aging, and Longevity in Model Organisms
- Type
- article
- Field-Weighted Citation Impact
- 0.95