Microbial Dominance in Diabetic Foot Osteomyelitis Determined With Nanopore Sequencing Techniques Predicts Positive Response to Surgical Intervention
In patients with surgically treated OM, nanopore sequencing can generate interpretable metagenomic data from bone specimens that are culture concordant and associated with clinical response. These findings support the feasibility and plausibility of using real-time metagenomic sequencing to improve the clinical management of OM.
Authors
- Robert P. Dickson (ORCID: https://orcid.org/0000-0002-6875-4277)
- John R. Erb‐Downward (ORCID: https://orcid.org/0000-0002-4233-758X)
- Piyush Ranjan (ORCID: https://orcid.org/0000-0001-8293-6889)
- Brian M. Schmidt (ORCID: https://orcid.org/0000-0002-2561-9243)
Institutions
- University of Michigan (US)
- Michigan Medicine (US)
- Ann Arbor Center for Independent Living (US)
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2025-12-06
- DOI
- https://doi.org/10.1093/infdis/jiaf617
- Primary Topic
- Orthopedic Infections and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00