Eutectogels: Recent Advances, Design Strategies, and Emerging Applications in Biotechnology

Eutectogels, obtained from the combination of deep eutectic systems (DESs) or natural deep eutectic systems (NADESs) with polymers, represent a new class of sustainable soft materials. Combining the tunable properties of DESs, such as low volatility, ionic conductivity, and biocompatibility, with the structural integrity of gels, these materials can be designed to have improved mechanical flexibility, self-healing ability, and environmental stability. Recent research focused on understanding how the composition of DESs, polymer type, or crosslinking mechanisms influence the physicochemical behavior and performance of eutectogels. Advances in this field enabled their use in diverse biotechnological applications, particularly in drug delivery, transdermal systems, wound healing, and tissue engineering, where they demonstrate improved biofunctionality and adaptability compared to traditional hydrogels. Nevertheless, challenges related to scalability, reproducibility, long-term stability, and toxicity must be addressed to reach their full potential. Progress in this area relies on multidisciplinary efforts between green chemistry, materials science, and bioengineering. Overcoming these hurdles could allow eutectogels to evolve from academic concepts into a new generation of sustainable, high-performance soft materials with broad applicability in the biotechnology field.