Colloidal Chemistry and Nanostructure Engineering of Gold Nanorods for Glioblastoma Applications

This study focuses on the synthesis and characterization of AuNRs optimized for glioblastoma treatment. Using controlled chemical processes, AuNRs with precise size and morphology were synthesized and characterized <i>via</i> dynamic light scattering and transmission electron microscopy. Cytotoxicity assays on glioblastoma (U87MG) and normal (HaCaT) cell lines evaluated their biocompatibility and selective cytotoxicity. Fluorescence microscopy and flow cytometry analyses revealed efficient cellular uptake via endocytosis, supporting their potential for targeted therapy. The results highlight AuNRs as a promising nanoplatform for overcoming key challenges in glioblastoma treatment, including selective tumor targeting and BBB penetration. This research advances precision medicine and underscores the transformative role of nanotechnology in developing next-generation glioblastoma therapies.