Depression and Anxiety Associate With Adverse Cardiovascular Events via Neural, Autonomic, and Inflammatory Pathways
Depression and anxiety independently associate with increased MACE risk, partly mediated by heightened stress-related neural activity and autonomic-immune dysregulation. The risk is greatest among those with both conditions, underscoring shared stress-related pathophysiology.
Authors
- Michael T. Osborne (ORCID: https://orcid.org/0000-0003-1001-1718)
- Sabeeh Islam
- Antonia V. Seligowski (ORCID: https://orcid.org/0000-0001-6946-6376)
- Shady Abohashem (ORCID: https://orcid.org/0000-0002-5033-8881)
- Giovanni Civieri (ORCID: https://orcid.org/0000-0002-3076-4787)
- Simran Grewal (ORCID: https://orcid.org/0000-0002-0675-1951)
- Ahmed Tawakol (ORCID: https://orcid.org/0000-0002-9211-5483)
- Wesam Aldosoky (ORCID: https://orcid.org/0000-0001-9282-2404)
- Sandeep Chandra Bollepalli (ORCID: https://orcid.org/0000-0002-9971-9335)
- Rachel Rosovsky (ORCID: https://orcid.org/0000-0002-2392-7365)
- Iqra Qamar
- Antonis A. Armoundas (ORCID: https://orcid.org/0000-0001-5006-1547)
- Lisa M. Shin (ORCID: https://orcid.org/0000-0002-9802-2261)
Institutions
- Broad Institute (US)
- Massachusetts General Hospital (US)
- Massachusetts Institute of Technology (US)
Publication Details
- Journal
- Circulation Cardiovascular Imaging
- Published
- 2025-12-17
- DOI
- https://doi.org/10.1161/circimaging.124.017706
- Citations
- 1
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.58