Paradoxical Normal‐Flow Aortic Stenosis Despite Reduced Left Ventricular Ejection Fraction: Insights From the Randomized COMPARE‐TAVI 1 Trial
NF-LEF is a prevalent aortic stenosis phenotype characterized by preserved flow despite reduced LVEF, likely driven by eccentric remodeling with moderate or worse aortic regurgitation and more favorable diastolic properties, with similar survival and time-to-event outcomes across phenotypes after transcatheter aortic valve implantation at long-term follow-up. Despite higher comorbidity burdens, patients with NF-LEF showed functional and clinical improvements comparable with normal flow, normal ejection fraction, indicating a severe aortic stenosis phenotype.
Authors
- Jonas Agerlund Povlsen (ORCID: https://orcid.org/0000-0001-9655-0493)
- Christian Juhl Terkelsen (ORCID: https://orcid.org/0000-0003-0205-9551)
- Evald Høj Christiansen (ORCID: https://orcid.org/0000-0002-8740-4862)
- Jordi Sanchez Dahl (ORCID: https://orcid.org/0000-0002-8345-204X)
- Steen Hvitfeldt Poulsen (ORCID: https://orcid.org/0000-0002-9586-835X)
- Troels Thim (ORCID: https://orcid.org/0000-0002-1014-5559)
- Henrik Nissen (ORCID: https://orcid.org/0000-0002-0842-3644)
- Marie-Annick A Clavel (ORCID: https://orcid.org/0000-0002-8924-740X)
- Rasmus Carter‐Storch (ORCID: https://orcid.org/0000-0002-0359-8728)
- Phillip Freeman (ORCID: https://orcid.org/0000-0003-1769-251X)
- Christian Alcaraz Frederiksen (ORCID: https://orcid.org/0000-0001-6583-2885)
- Emil Johannes Ravn (ORCID: https://orcid.org/0000-0002-8992-5493)
- Frederik Uttenthal (ORCID: https://orcid.org/0009-0008-4787-3980)
- Ulrik Christiansen (ORCID: https://orcid.org/0000-0002-7624-8454)
Institutions
- University of Southern Denmark (DK)
- Aalborg University Hospital (DK)
- Odense University Hospital (DK)
- Aarhus University Hospital (DK)
- WinnMed (US)
- Mayo Clinic in Arizona (US)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2025-12-17
- DOI
- https://doi.org/10.1161/jaha.125.045521
- Primary Topic
- Cardiac Valve Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Aarhus Universitet
- Aarhus Universitetshospital
- Odense Universitetshospital