Blood–Brain Barrier Permeability Dynamics and Mediation of Triglyceride–Glucose Index on Acute Ischemic Stroke Outcomes
FED values were higher in the core and increased over time, contributing to worse outcomes. An elevated TyG index mediates worse outcomes through increased BBB permeability, highlighting BBB stabilization as a potential therapeutic target.
Authors
- Lianfang Shen (ORCID: https://orcid.org/0000-0002-9380-2955)
- Shuang Xia (ORCID: https://orcid.org/0000-0003-1626-6383)
- Chenxi Zhao (ORCID: https://orcid.org/0000-0002-1646-645X)
- Huiying Wang (ORCID: https://orcid.org/0000-0003-1612-4203)
- F. Wang (ORCID: https://orcid.org/0009-0007-3074-3402)
- Yu Guo (ORCID: https://orcid.org/0000-0002-5678-9552)
- Yue Cheng (ORCID: https://orcid.org/0000-0003-3159-4924)
Institutions
- Binzhou Medical University (CN)
- Tianjin First Center Hospital (CN)
- Yidu Central Hospital of Weifang (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2025-12-17
- DOI
- https://doi.org/10.1161/jaha.125.041620
- Citations
- 1
- Primary Topic
- Barrier Structure and Function Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.84