Targeting of Cdc42‐Interacting Protein 4‐Calcineurin Signalosomes Improves Cardiac Structure and Function After Myocardial Infarction
CIP4-CaNAβ2 signalosomes promote adverse cardiac remodeling and are not cardioprotective. Proof of concept is provided for the treatment of ischemic cardiomyopathy by a polyproline peptide gene therapy. Targeting these complexes may be beneficial in cardiovascular diseases, including ischemic cardiomyopathy and acute myocardial infarction.
Authors
- Kimberly L. Dodge‐Kafka (ORCID: https://orcid.org/0000-0003-0500-5698)
- Michael S. Kapiloff (ORCID: https://orcid.org/0000-0002-7005-6953)
- Pilar Alcaide (ORCID: https://orcid.org/0000-0003-3013-3982)
- Abraham Bayer (ORCID: https://orcid.org/0000-0001-7534-6354)
- Anne‐Maj Samuelsson (ORCID: https://orcid.org/0000-0002-6317-2016)
- Moriah Gildart Turcotte (ORCID: https://orcid.org/0000-0002-4622-2720)
- Yang Li (ORCID: https://orcid.org/0000-0002-0736-251X)
- Jinliang Li (ORCID: https://orcid.org/0000-0002-3018-0570)
- DeEsmond Lewis
Institutions
- Tufts University (US)
- Cardiovascular Institute of the South (US)
- Stanford Medicine (US)
- UConn Health (US)
- Stanford University (US)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2025-12-17
- DOI
- https://doi.org/10.1161/jaha.125.044692
- Primary Topic
- Signaling Pathways in Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00