Sarco/Endoplasmic Reticulum Ca <sup>2+</sup> ATPase Activation Shifts Cardiac Fuel Preference Without Impairing Cardiac Function in Obese Mice

SERCA activation promotes flux from nonglucose substrates to fuel cardiac mitochondrial metabolism in obese mice.

Authors

Mohsin Rahim (ORCID: https://orcid.org/0000-0001-8407-5621)
Jamey D. Young (ORCID: https://orcid.org/0000-0002-0871-1494)
David A. Jacobson (ORCID: https://orcid.org/0000-0003-1816-5375)
Deveena R. Banerjee (ORCID: https://orcid.org/0000-0002-0750-5138)
Clinton M. Hasenour (ORCID: https://orcid.org/0000-0002-9887-0922)
Amanda C. Doran (ORCID: https://orcid.org/0000-0002-1576-6274)
T. Bednarski (ORCID: https://orcid.org/0000-0001-9200-8154)

Institutions

Vanderbilt University (US)
Vanderbilt University Medical Center (US)

Publication Details

Journal: Journal of the American Heart Association
Published: 2025-12-17
DOI: https://doi.org/10.1161/jaha.125.042505
Primary Topic: Mitochondrial Function and Pathology
Type: article
Field-Weighted Citation Impact: 0.00

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article

Sarco/Endoplasmic Reticulum Ca ²⁺ ATPase Activation Shifts Cardiac Fuel Preference Without Impairing Cardiac Function in Obese Mice

Mohsin Rahim, Jamey D. Young, David A. Jacobson, Deveena R. Banerjee et al.

Dec 17, 2025

Journal of the American Heart Association

Mitochondrial Function and Pathology

article

Sarco/Endoplasmic Reticulum Ca ²⁺ ATPase Activation Shifts Cardiac Fuel Preference Without Impairing Cardiac Function in Obese Mice

Mohsin Rahim, Jamey D. Young, David A. Jacobson, Deveena R. Banerjee, Clinton M. Hasenour, Amanda C. Doran, T. Bednarski

December 17, 2025article en

Abstract

SERCA activation promotes flux from nonglucose substrates to fuel cardiac mitochondrial metabolism in obese mice.

Journal of the American Heart AssociationVol. 15(1)

Vanderbilt University (US), Vanderbilt University Medical Center (US)

Openalex Percentile: Top 63%

Mitochondrial Function and Pathology

DOI Open Access PDF OpenAlex

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