Lymphatic Endothelial C‐C Motif Chemokine Ligand 2 Enhances Lymphangiogenesis and Lymphatic Clearance of Macrophages Following Myocardial Infarction
This study reveals that cardiac LEC-expressing CCL2 tightly controls macrophage trafficking via lymphatic vessels in injured hearts and thus diminishes post-MI inflammatory responses and lessens adverse cardiac remodeling. Our findings suggest that modulating CCL2 signaling in LECs could provide a promising therapeutic target for resolving excessive inflammation and ameliorating adverse cardiac remodeling after MI.
Authors
- Jinjin Wu (ORCID: https://orcid.org/0009-0001-1021-2408)
- Q. Susan Li (ORCID: https://orcid.org/0009-0000-5547-704X)
- Yunhao Duan (ORCID: https://orcid.org/0000-0003-1710-1783)
- Shengqiong Deng (ORCID: https://orcid.org/0000-0003-2855-6150)
- Caixia Zhou (ORCID: https://orcid.org/0009-0002-5112-2764)
- Kaiming Zhao (ORCID: https://orcid.org/0009-0008-7083-8323)
- Shan Li (ORCID: https://orcid.org/0000-0002-9995-989X)
- Lin Zhang (ORCID: https://orcid.org/0000-0003-1961-7812)
- Zhen Cai (ORCID: https://orcid.org/0009-0001-5822-7502)
- Yu Luo (ORCID: https://orcid.org/0000-0001-8044-7096)
Institutions
- Tongji University (CN)
- University of Shanghai for Science and Technology (CN)
- Second Military Medical University (CN)
- Shanghai Jiao Tong University (CN)
- Shanghai Children's Medical Center (CN)
- Ningxia Medical University (CN)
- Shanghai East Hospital (CN)
- Shanghai Pudong New Area Gongli Hospital (CN)
- Zigong First People's Hospital (CN)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2025-12-17
- DOI
- https://doi.org/10.1161/jaha.124.039153
- Citations
- 1
- Primary Topic
- Lymphatic System and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.05