METTL3‐m6A‐SLC25A11 Axis Promotes Chronic Hypoxia–Induced Cardiomyocyte Ferroptosis
This study is the first to demonstrate the protective effect of methyltransferase-like 3 inhibition, via SLC25A11 m6A modification, against chronic hypoxia-induced cardiomyocyte ferroptosis and reveals the possibility that inhibiting activation of methyltransferase-like 3-m6A-SLC25A11 may provide cardioprotective therapy for chronic hypoxia-induced cardiovascular diseases.
Authors
- Yong Wei (ORCID: https://orcid.org/0000-0002-3314-118X)
- Guibin He (ORCID: https://orcid.org/0000-0003-4272-2960)
- Yan Zhu
- Yansong Li (ORCID: https://orcid.org/0009-0000-7196-5959)
- Mao-rong He
- Jingwen Xia
Institutions
- China Guodian Corporation (China) (CN)
- Baoshan University (CN)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2025-12-17
- DOI
- https://doi.org/10.1161/jaha.125.041690
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00